crabjoe:

Hit them until they die. There is no easier way.

Don Yellman, Great Falls, VA

One recipe I have heard is cut to ground and slather 100% strength 2,4-D or similar on the fresh wound. I am in the process of killing a couple dozen wild grapevines myself this spring and I mainly just keep pruning them back to nothing over and over, plus spraying Roundup on the more persistent ones.

Scott

I would switch from Weed Be Gone to Brush be Gone, and just keep at it until it does not come back. Al

2,4-D is really deadly to grapes, so if you have cultivated grapes nearby that you do not want to kill, be very careful with regard to drift from the spray. Scott's method will definitely do the job, and should only require doing it once.

We have one, too. I personally really like the greenery it adds to our property that has no trees. However, the original root of this thing came up directly under/behind our Central AC unit at the back corner of the house. We can't get in there to dig to dig or cut, but I will try the 2,4D and/or the Brush Be Gone. It is pretty close to my ornamental grass garden, so I will have to watch that drift. Thanks for the tips, guys!

I have mustang grapes climbing up pecan trees...choking the trees. How can I get rid of them without harming the pecan trees?

Like they said the best way is to cut it off at the base and then paint the fresh cut with 24D or brushkiller. It will seep into the stump and kill it. You might have to do it a couple times but usually once is enough.