| There is also indication in the literature (findable on Google) that it does something permanent to the smooth muscle; here is a quote that does not appear to be copyrighted: "Newsgroups: alt.folklore.herbs Subject: feverfew: effective but possibly dangerous From: MORAVCSIK.CLIPR.COLORADO.EDU (Julia Moravcsik) Date: 15 Jun 1995 17:52:31 GMT I looked up feverfew in Medline and would like to report what I found there. If you aren't interested in medical experimentation as it applies to herbs, you will probably not be interested in what follows. The good news (for migraine sufferers): I found two double blind experiments looking at the effectiveness of feverfew on migraines: The first one used 72 migraine sufferers. Half got a capsule per day of feverfew, the other half got a placebo. There was a significant reduction in the mean number and severity of migraine attacks. The other experiment looked at 17 migraine sufferers who normally ate feverfew to control headaches. They gave placebos to some and continued the feverfew with others. The placebos increased frequency and severity of migraines. The bad news: Feverfew affects the smooth muscles of the body. These are muscles that control much of your involuntary muscular processes, such as the vascular system (blood vessels), digestive system, internal organs, aorta, etc. From what I can gather from some of the abstracts in Medline, feverfew PERMANENTLY affects the ability of these smooth muscles to contract and relax. Here are some snippets from the abstracts which looked at this: "(Feverfew)...inhibits smooth muscle contractibility in a time-dependent, non-specific, and irreversable manner." "(Feverfew)...affects smooth muscles...may represent a toxic modification of post-receptor contractile function in the smooth muscle...effects are potentially toxic" "...inhibition of eicosanoid generation is irreversable" "...irreversable loss of tone of precontracted aortic rings...inhibited ability of acetylcholine to enduce endothelium dependent relaxation of tissue." What does this all mean for the long term health of those who take feverfew? That does not seem to have been looked at yet; these articles were very recent. However, I think that people who take feverfew should know that they may be permanently affecting the smooth muscles in their bodies and may want to take this into account when deciding whether or not to continue taking it. " I'm not certain what this implies but maybe some others on this board can tell us. There are quite a few testaments to feverfew on the internet by migraine sufferers; maybe the effect on smooth muscle is part of the reason. |