Pyola is a pyrethron based broad spectrum pesticide that will not help if what you have is a fungal disease. However, since what you have is eating holes in the leaves it may well be an insect, but never start any control program with the most toxic substance available.
Look over the plant to see if you can see what is eating holes in the leaves and causing the leaves to turn yellow and brown, and then find the least toxic means of control for that and use that method. It might be as simple as a sharp water spray or hand squishing the culprit(s).

I tried Neem oil, diatomaceous earth, and hot pepper wax to no avail to fight my bug invasions. Spraying with either Spinosad or Pyola regularly (about once a week) is helping to keep the bugs at bay.

The instructions say that you can use Pyola up to the day before harvest. It breaks down fairly quickly.