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Which is more important roses with no fungus or curing people?

Posted by henry_kuska z5 OH (kuska@neo.rr.com) on
Fri, Jul 19, 13 at 0:30

Which is more important: roses with no fungus or people with limited treatment options when they get an azole resistant fungus,?

"Abstract
Fungal diseases are problematic in both human health and agriculture. Treatment options are limited and resistance may emerge. The relatively recent recognition of triazole resistance in Aspergillus fumigatus has prompted questioning of the origin of resistance. While multiple mechanisms are described in clinical isolates from triazole-treated patients, some de novo resistance is also recognized, especially attributable to TR34/L98H. Such strains probably arose in the environment and indeed multiple studies have now demonstrated TR34/L98H triazole resistance strains of A. fumigatus from soil. Docking and other in vitro studies are consistent with environmental resistance induction through exposure to certain triazole fungicides, notably difenoconazole, propiconazole, epoxiconazole, bromuconazole and tebuconazole. This article addresses the potential implications of this issue for both human health and food security.".

Here is a link that might be useful: 2013 scientific research paper


Follow-Up Postings:

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RE: Which is more important roses with no fungus or curing people

A better question might be--why are the treatment options so limited? When I made my career choice 30 years ago I went into engineering rather than science--the job opportunities for talented scientists were dismal back them. They aren't any better today for budding scientists.

Even worse, folks with Asperger's, bright autistic kids that are our best hope at finding cures to rare diseases, aren't getting the opportunities to discover and excel in their gifts--like athletes. Instead, they now get opportunities to be "normal." Special classes and training at an early age to fit in with others. Might it make more sense to have a more accepting society of folks that are different--so they can use their gifts to benefit society? Or is that just not possible?

Like it or not, diseases evolve to evade our cures. Making it harder for companies to further research into new cures is counterproductive.


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RE: Which is more important roses with no fungus or curing people

One possible answer to the question as to why are the treatment options so limited is that Nature only uses a limited number of biological pathways. Thus, something that affects a pathway in a fungus that affects plants will probably also affect a pathway of a fungus that affects humans. The same goes for other living things. The link below is a recent example of a chemical affecting pathways other than the intended pathway.

"Neonicotinoids and related pesticides may be suppressing the immune system of bees, bats and even amphibians, making them much more susceptible to parasites, viruses and fungal infections, according to an international team of researchers who recently published their findings in the Journal of Environmental Immunology and Toxicology.

Insects feeding on the pollen and nectar of crops treated with the pesticides absorb the chemicals and the poison is subsequently passed on to animals higher up the food chain that prey on those bugs, the scientists hypothesize, citing evidence of deviation from normal pathogen-host relationships."

Here is a link that might be useful: insecticide affecting immune systems higher up the food chain


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